Isabelle Machado de Holanda
Universidade de São Paulo, Brazil
Title: Associated dental anomalies and the genetic aetiology: A twins study case
Biography
Biography: Isabelle Machado de Holanda
Abstract
The influence of genetic factors in the etiology of associated dental anomalies is the hypothesis of several study cases in families. Studies of genes and interacting molecular pathways have shown the genetically and phenotypically heterogeneity of the condition. Tooth agenesis constitutes the most common developmental anomaly of the human dentition and is frequently associated with other dental anomalies, including ectopia, microdontia and enamel hypoplasia. The prevalence of agenesis is higher in families of affected patients. These evidences highlight the importance of early diagnosis and timely intervention. Also the recognition of the pattern of associated dental anomalies in the same family members. This article aims to present a monozygotic twin sisters study case of agenesis, microdontia, ectopia and delayed dental development demonstrating the high genetic contribution in the etiology of associated dental anomalies. A high correlation for a particular irregularity in pairs of monozygotic twins is evidence that genetics is an important etiology of such abnormality. Unlikely, dizygotic twins which have different genotypes would show a lower correlation for the same irregularity.